“The fund maintained a short position in Karuna Therapeutics based on skepticism over Phase 3 clinical trial design for its schizophrenia drug KarXT. The short generated losses after Bristol-Myers Squibb announced an acquisition offer of $14 billion for the company ahead of FDA approval.”
Each excerpt above is the manager's commentary on this ticker specifically. The full letter has the rest of their portfolio thinking, risk discussion, and broader institutional context.